Project Title: The East-South Africa Anopheles Funestus Consortium: Building the capacity for An. funestus entomological surveillance, insectide resistance and genomic diversity studies in Malawi, Kenya , Uganda and Tanzania
Project Description: Vector control is primarily based on indoor functioning long lasting insecticidal nets (LLINs) and indoor residual spraying (IRS), both of which are insecticide based. The emergence and spread of insecticide resistance (IR) is hence considered as a primary barrier to effective functioning of these interventions. Entomology surveillance including IR evaluation is usually carried out as part of routine monitoring efforts for National Malaria Control Program (NMCPs) implementing vector control. At present, data is available for... Vector control is primarily based on indoor functioning long lasting insecticidal nets (LLINs) and indoor residual spraying (IRS), both of which are insecticide based. The emergence and spread of insecticide resistance (IR) is hence considered as a primary barrier to effective functioning of these interventions. Entomology surveillance including IR evaluation is usually carried out as part of routine monitoring efforts for National Malaria Control Program (NMCPs) implementing vector control. At present, data is available for An. gambiae and An. arabiensis in Tanzania, Uganda and Kenya, however, very little data (especially on IR) is available on An. funestus even though it is often the more abundant species and with the highest proportion of Plasmodium sporozoite individuals. This study seeks to fill vital knowledge gaps that pose a serious barrier to malaria elimination and aims to comprehend the temporal effects of indoor residual spray with Actellic CS, on population bottlenecks, genome structure and gene-flow in An. funestus allowing for the measurement of actual effect based on overlapping intervention-susceptible bionomic traits, with comparison to non-treatment areas. these findings will enable the streamlining of intervention strategies based on demonstrated impact, and can be applied to any vector interventions-including gene-drive systems where gene-flow is vital for impact.
Principal Investigator : Faraji Abilahi
Department Name :
Time frame: (2019-06-01) - (2021-12-31)
Bill and Melinda Gates Foundation (BMGF) (Normal)
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